How is sensitization defined in relation to pesticide exposure?

Sensitization in the context of pesticide exposure refers to a process where the first encounter with a particular substance, such as a pesticide, primes the immune system, making it more reactive to that substance upon subsequent exposures. This phenomenon often results in an allergic response, which may manifest as symptoms like skin irritations, respiratory issues, or other allergic reactions that were not present with the initial exposure.

Understanding sensitization is critical for risk assessment in pesticide use and application, as even a single exposure can lead to heightened sensitivity, meaning that future exposures could trigger adverse reactions. This underscores the importance of safety measures and monitoring in environments where pesticides are used, as early awareness and protective actions can prevent sensitization from leading to more serious health issues.